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KMID : 0361020060490121145
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Korean Journal of Otolaryngology - Head and Neck Surgery
2006 Volume.49 No. 12 p.1145 ~ p.1150
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Allele Distribution of Human Surfactant Protein A in Otitis Media with Effusion
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Han Kyung-Yuhl
Oh Cheon-Hwan
Chang Hyuk-Soon
Kim Jang-Moog
Kim Sung-Woon
Oh Myung-Ho
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Abstract
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Background and Objectives : Surfactant protein A (SP-A) which plays a role in the innate host defense of lung is also expressed in Eustachian tube. However the genes underlying the susceptibility to otitis media with effusion (OME) are known insufficiently. The current study attempts to evaluate the difference in the allele distribution of SP-A1 and SP-A2 between normal subjects and subjects with otitis media with effusion.
Subjects and Method : PCR-cRFLP-based methodology was used to detect SP-A genotypes in the 38 children with OME, and in the 55 normal newborns for control.
Results : The frequencies of specific genotypes such as 6A(2), 1A(2) were increased in OME group, but the frequency of 6A3 was increased in control group.
Conclusion : It is presumed that SP-A alleles may be inductive (6A(2), 1A(2)) or protective (6A(3)) factors for OME. Specific genoytypes of SP-A may be an important determinant for the predisposition to OME.
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KEYWORD
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Otitis Media with Effusion, Surfactant Protein A, PCR-cRFL
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